Tamoxifen-loaded PLGA nanoparticles: preparation and characterization

MERARI CHEVALIER; NICOLETTA RESCIGNANO; JOSÉ KENNY; VERA ALVAREZ

Granada

Conferencia; XI Spanish-Portuguese Conference on Controlled Drug Delivery ("Revolutionary Approaches in Nanomedicine Development"); 2016

Depending upon the dose and the concentration Tamoxifen (TMX) has several side effects, such as endometrial carcinoma for postmenopausal women. Other side effects include liver cancer, venous thrombosis, pulmonary emboli, and an ocular effect includes retinopathy and corneal opacities. PLGA posses attractive features for drug delivery such as protection of drug from degradation, possibility of sustained release, possibility to modify surface properties to provide stealthness and/or better interaction with biological materials and possibility to target nanoparticles to specific organs or cells.