Chemistry and Biological Activity of Coumarins at Molecular Level

HUGO A. GARRO; CELINA GARCÍA; VÍCTOR S. MARTÍN; CARLOS E. TONN; CARLOS R. PUNGITORE

NATURAL PRODUCT COMMUNICATIONS

NATURAL PRODUCTS INC

Lugar: Westerville, Ohio; Año: 2014 vol. 9 p. 1091 - 1094

1934-578X

Synthetic coumarins were prepared using ionic liquids as an environmental friendly alternative with high yields. The compounds 3,4-dimethyl-7-hydroxycoumarin (3ab) and 3-isopropyl-4-methyl-5,7-dihydroxycoumarin (3bc) have showed interesting activity against Taq DNA polymerase with IC50 values of 115.74 μM and 82.24 μM, respectively. Also, the compounds 4-methyl-7-hydroxycoumarin (3aa) and 4-methyl-5,7-dihydroxycoumarin (3ba) have exhibited inhibitory activity against MMLV-RT with IC50 values of 23.46 μM and 18.35 μM, respectively. These inhibitors could have importance as antiretroviral chemotherapeutic agents and also in the development of antitumor drugs.