157) EFFECTS OF THE COMBINATION OF TRANILCIPROMINE AND RESVERATROL IN LOW DOSES IN THE FORCED SWIMMING TEST.

MARTIN CUNIETTI, J.; LORENZO, S.; GUEVARA MA; GARGIULO, P.A.

Mendoza

Simposio; IIº International Symposium of Translational Medicine. XII Annual Meeting of Investigation at the Faculty of Medical Sciences. Mendoza. 7 a 8 de marzo de 2019.-; 2019

Facultad de Ciencias Médicas. Universidad Nacional de Cuyo.

157) Martín Cunietti J, Lorenzo S, Guevara M, Gargiulo P. Effects of the combination of Tranilcipromine and Resveratrol in low doses in the Forced Swimming Test. IIº International Symposium of Translational Medicine. XII Annual Meeting of Investigation at the Faculty of Medical Sciences. Mendoza. 7 a 8 de marzo de 2019.-http://fcm.uncuyo.edu.ar/prorroga-para-cargar-resumenes-a-las-xiv-jornadas-de-investigacion-fcm-y-el-ii-simposio-de-medicina-traslacionalEFFECTS OF THE COMBINATION OF TRANILCIPROMINE AND RESVERATROL IN LOW DOSE IN THE FORCED SWIMMING TEST. Authors: Martín Cunietti J, Lorenzo S, Guevara M, Gargiulo P. Laboratory of Neuroscience and Experimental Psychology. Pharmacology Area. Department of Pathology. Faculty of Medical Sciences. National University of Cuyo. Introduction: The prevalence of major depression makes it one of the psychiatric disorders that produces the greatest disability worldwide (300 million people, WHO, 2017). There are several antidepressants, among which are Monoamine Oxidase Inhibitors (MAOIs). Despite its high effectiveness, the use of MAOIs has currently been limited for patients with depression refractory to other treatments, mainly due to the risk of hypertensive crisis in the event of intake of foods rich in tyramine. Tranilcipromine (T) is a MAOI, and has shown a potent antidepressant effect in the forced swimming test in rodents. Resveratrol (R) (3, 5, 4´-39; -trihydroxy-trans-stilbene) is a Stilbenoid (natural phenol) that is produced in several plants, and has shown compatible actions with an antidepressant effect in this test.Hypothesis: The combined use of tranylcypromine and resveratrol would produce the potentiation of its antidepressant effects.Objectives: Verifying that the sum of low doses of tranylcypromine and resveratrol, which have no antidepressant effect, have an additive or enhancing effect when combined.Methods: Male rats derived from the Holtzman strain (280-320 g) were subjected to the forced swim test. They were divided into two groups: Controls (saline + saline, n=15) and Tranylcypromine (5 mg / kg) + Resveratrol (60 mg / kg, n=15).Results: A significant decrease in resting time was observed (p