Pediatric Glucose Regulation without Pre-Meal Insulin Boluses: An Approach based on Switched Control and Time-Varying IOB Constraints.

EMILIA FUSHIMI; CECILIA SERAFINI; HERNÁN DE BATTISTA; FABRICIO GARELLI

Madrid

Conferencia; 13th International Conference on Advanced Technologies & Treatments for Diabetes; 2020

AP systems have shown to improve glucose regulation in T1D patients. However, full closed-loop performance remains a challenge particularly in children and adolescents, since these age groups often present the worst glycemic control.In this work, a new algorithm based on switched control and time-varying IOB constraints is presented (ARGAE). This method is a combination of ideas from the previously introduced Automatic Regulation of Glucose (ARG) algorithm, which features no pre-meal insulin boluses [1], and the Amplitude Enable (AE) mode, which allows the controller to act more aggressively at the beginning of meal intake without risking postprandial hypoglycemia [2]. The proposed control strategy is evaluated in silico and its performance contrasted with the ARG algorithm in the pediatric population. Simulations show that the proposed algorithm improves the performance of the ARG algorithm.