Antibodies against Yersinia enterocolitica in synovial liquid of patients with rheumatoid arthritis or spondyloarthropathies correlate with anti-type I collagen antibodies.

LACOSTE G; TAMASHIRO H,; GUZMÁN A; CORREA S; DI GENARO S.

Córdoba, Argentina

Congreso; VII Congreso Latinoamericano de Inmunología; 2005

Asociacion Latinoamericana de Inmunología (ALAI)

The aim of the present work was to correlate the antibody reactivity to Yersinia antigens in synovial liquids (SL) of patients with rheumatoid arthritis (RA) or spondyloarthropathies (SpA) with anti-collagen type I and II  antibodies. Total immunoglobulins (IgG+IgA+IgM) and IgA against Y. enterocolitica O:8 were investigated by ELISA. We used lipopolysaccharide (LPS), culture supernatant proteins (SN), and the whole bacteria disrupted by sonication (SO) as antigens. Additionally,  antibodies to type I and II collagen were determined. We found a significant correlation between total immunoglobulins to Yersinia and to type I collagen (Spearman r = 0.81; 95% CI 0.6 to 0.9; p< 0.0001). Moreover, levels of IgA antibodies against Yersinia antigens also correlated with anti-type I collagen antibodies (Spearman r = 0.6; 95% CI 0.2 to 0.8; p< 0.002). In contrast, the correlation was not significant between anti-type II collagen and anti-bacterial antibodies (Spearman r = 0.3; 95% CI –0.14 to 0.6; p= 0.2). We concluded that there is different reactivity to articular collagen in patients with Yersinia antibodies.