Association between levels of synovial anti-citrullinated peptide antibodies and neutrophil response in patients with rheumatoid arthritis

CAROLINA V. GORLINO; MABEL N. DAVE; RODRIGO BLAS; MARÍA I. CRESPO; ALICIA LAVANCHY; HÉCTORTAMASHIRO; RODOLFO PARDO-HILDALGO; MARÍA C. PISTORESI-PALENCIA ; MARÍA S. DI GENARO

EUROPEAN JOURNAL OF IMMUNOLOGY

WILEY-V C H VERLAG GMBH

Lugar: Weinheim; Año: 2018

0014-2980

Rheumatoid arthritis (RA) is characterized by the presence of anti-citrullinated peptide antibodies (ACPAs) and neutrophils infiltrating the synovial fluid (SF) of the affected joints. The aim of this work was to analyze whether the presence of ACPAs in SF is associated with neutrophil infiltration and with their phenotype in the inflamed joints of RA patients. We found that in the presence of ACPAs, the number of synovial neutrophils correlated with severe disease activity. The SF were divided according to synovial ACPA levels in negative-(