INVESTIGADORES
DI GENARO Maria silvia
artículos
Título:
IgA response by oral infection with an attenuated Yersinia enterocolitica mutant:
Autor/es:
HELGA M. BLANCO; MARÍA G. LACOSTE; RICARDO J. ELIÇABE; MARÍA S. DI GENARO
Revista:
VACCINE
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 2008 vol. 26 p. 6497 - 6502
ISSN:
0264-410X
Resumen:
Yersinia enterocolitica (Ye) mutant strain (sycH-) is unable to secrete the virulence protein YopH. Mucosal vaccination is often required to induce protection, but stimulating strong IgA response is frequently difficult. Here, we addressed whether Ye sycH- might induce IgA response, and investigated its attenuation in TNFRp55−/−, IL-12p40−/− and IL-4−/− mice. We found that Ye sycH- colonizes Peyers patches, and induces higher Yersinia-specific IgA levels in feces and in serum compared with Ye wild type. The Ye sycH mutant proved to be attenuated and induced IgA in both wild-type and immunodeficient mice. These lines of evidence show the attenuation of Ye sycH- and its ability to stimulate an IgA response. This mutant might be useful as an oral vaccine carrier.
