INVESTIGADORES
FRONTINI patricia Maria
artículos
Título:
Mechanical behavior of bilayered small-diameter nanofibrous structures as biomimetic vascular grafts
Autor/es:
FLORENCIA MONTINI BALLARIN; DANIEL CALVO; PABLO C. CARACCIOLO; FRANCISCO ROJO; G. A. ABRAHAM; PATRICIA M FRONTINI; GUSTAVO V. GUINE
Revista:
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2016
ISSN:
1751-6161
Resumen:
To these days, the production of a small diameter vascular graft (o6 mm) with anappropriate and permanent response is still challenging. The mismatch in the graftsmechanical properties is one of the principal causes of failure, therefore their completemechanical characterization is fundamental. In this work the mechanical response ofelectrospun bilayered small-diameter vascular grafts made of two different bioresorbablesynthetic polymers, segmented poly(ester urethane) and poly(L-lactic acid), that mimic thebiomechanical characteristics of elastin and collagen is investigated. A J-shaped responsewhen subjected to internal pressure was observed as a cause of the nanofibrous layeredstructure, and the materials used. Compliance values were in the order of natural coronaryarteries and very close to the bypass gold standard-saphenous vein. The suture retentionstrength and burst pressure values were also in the range of natural vessels. Therefore, thebilayered vascular grafts presented here are very promising for future application as smalldiametervessel replacements.