Biomonitoring of the hematological, biochemical and genotoxic effects of the mixture cypermethrin plus chlorpyrifos when applied to bovines

D. M. FERRÉ,; PAOLA J. JOTALLÁN,; VALERIA R. LENTINI; LUDUEÑA HÉCTOR R.; R. RAQUEL ROMANO,; N GORLA,

SCIENCE OF THE TOTAL ENVIRONMENT

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2020

0048-9697

External antiparasitic agents applied in bovine production represent a risk to consumers of meat products, especially if the conditions of their use are not strictly respected. The post-mortem control of residues in meat is an activity that must be updated and reinforced by the biomonitoring of live animals and the use of analytical tools to help identify signs of early warning risks. The objective of the present study was to carry out a pre-slaughter biomonitoring approach in Aberdeen Angus cattle and crosses (n=12) with the application of a commercial formulation of cypermethrin + chlorpyrifos. This was performed with a single therapeutic dose applied on the backs of the cattle, through hematological, enzymatic, as well as hepatic and renal function analysis in plasma, and then observing the genotoxic effect on lymphocytes. Analytical measurements of plasma concentrations of cypermethrin + chlorpyrifos at 24h were negative and therefore a low absorption of the compounds was assumed. Measurement of acetyl cholinesterase showed no inhibition after exposure. The concentration of urea increased between 24 h y 168 h post application of the formulation, but without showing any kidney damage. The rest of the parameters analyzed did not show any variations. This evaluation of hematological and biochemical effects and of cytokinesis- block micronucleus cytome assay in bovines is proposed as a pre-slaughter control of biomonitoring of the health status of animals, with a focus on food safety for meat consumers.