COMPARATIVE PHARMACOKINETICS OF ENROFLOXACIN AND CIPROFLOXACIN IN CHICKENS

H. GARCÍA OVANDO; N. GORLA; C. LUDERS; G. POLONI; C. ERRECALDE; G. PRIETO; I. PUELLES

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

WILEY-BLACKWELL PUBLISHING, INC

Año: 1999 vol. 22 p. 209 - 212

0140-7783

Summary Pharmacokinetic parameters of disposition for antimicrobials Enrofloxacin (EFX) and Ciprofloxacin (CFX) were comparatively analyzed in broiler chickens after single intravenous dose of 5 mg/ Kg as bolus. Blood was taken in different preset times: 0.00, 0.03, 0.06, 0.13, 0.25, 0.5, 1, 2, 4, 8, 12 and 24 h after the administration. The concentrations of EFX and CFX in plasma were determined by High Pressure Liquid Chromatography. The concentration values of the antimicrobials versus time were analyzed by a compartmental independent pharmacokinetic model by which the robust pharmacokinetic parameters were obtained. Statistically significant differences between the two antimicrobials were found for most of the pharmacokinetic parameters variables: Area under the curve (AUC), area under first moment curve, mean residence time (MRT), total cleareance (tCl), volume of distribution beta and volume of distribution at the steady state. Both antimicrobials were widely distributed in chickens throughout the body with a mean Vdss value of 1.98 + 0,18 L/ Kg for EFX, and 4.04 + 0.69 for CFX. The value of tCl for CFX was 5 times higher than the obtained for EFX. It was also observed that AUC, MRT and the terminal disposition rate constant for EFX were two- four times higher than those obtained for CFX. These results are indicating that CFX remains in the body less time than the other quinolone. This characteristic of CFX suggests the advantage of a minor withdrawal time for animals treated with this antimicrobial.and volume of distribution at the steady state. Both antimicrobials were widely distributed in chickens throughout the body with a mean Vdss value of 1.98 + 0,18 L/ Kg for EFX, and 4.04 + 0.69 for CFX. The value of tCl for CFX was 5 times higher than the obtained for EFX. It was also observed that AUC, MRT and the terminal disposition rate constant for EFX were two- four times higher than those obtained for CFX. These results are indicating that CFX remains in the body less time than the other quinolone. This characteristic of CFX suggests the advantage of a minor withdrawal time for animals treated with this antimicrobial.