A bacterial protease inhibitor delivered subcutaneously limits APCs lysosomal proteolysis and increases immunogenicity of co-administered Ag

CORIA L, IBAÑEZ AE, CARAVAJAL M, BERGUER P, BRUNO L, RISSO G, GONZALEZ COBIELLO PL, FRANK FM, PASQUEVICH KA, CASSATARO J.

Seattle

Simposio; Keystone Symposia "The Modes of Action of Vaccine Adjuvants"; 2014

Ourprevious results demonstrated that a Brucellaspp. protein (Bp) is a broad spectrum protease inhibitor as it can inhibitproteases present in the stomach and gut (mostly serine proteases). In this workwe demonstrated that Bp also possesses inhibitory activity on lysosomal proteases(cysteine proteases). Bp partially reduced the proteolytic activity ofcommercial cysteine proteases in vitro (P