Levels of Bone Turnover in Saliva Correlated with Antirresortive Treatment: Experimental Study.

PELLEGIRNI G,; GONZALE CHAVES MACARENA MS; ZENI CORONEL MAGALÍ; AVENDAÑO ME; BONANNO MARINA SOLEDAD; ZENI SUSANA N

Austin Journal of Dentistry

Austin Publishing Group

Lugar: Irving Texas; Año: 2020 vol. 7 p. 1145 - 1150

2381-9189

Background: Bone turnover markers are useful to evaluate bone loss andmonitor anticatabolic treatments in a short period. The effectiveness of salivato reflect changes in bone turnover markers during the early administrationof different doses of olpadronate (POD) (4 mg or 8 mg/100 g body weight),immediately after Ovariectomy (OVX), was evaluated.Material and Methods: Adult rats (n=10/group) were divided and treatedas follows for 45 days: SHAM+Vh; OVX+Vh; OVX+4OPD and OVX+8OPD. Tovalidate the model, we measure Proximal Tibia Bone Mineral Density (PTBMD)change between the beginning and the end of the study. Blood and saliva werecollected post-surgery (t=0; t=10; t=20; t=45).Results: PTBMD decrease in OVX+Vh was partially prevented by 4OPDand avoided by 8OPD. Salivary and serum β-CrossLaps (CTX) in SHAM+Vhremained without changes and increased in OVX+Vh (p