“Sorption of compressed CO2 in biopolymers for developing drug delivery Systems”.

M.A. FANOVICH, P. JAEGER,

Los Cocos, Argentina

Simposio; V SIMPOSIO CHILENO-ARGENTINO DE POLÍMEROS; 2009

ARCHIPOL

This work is focused on determining diffusivity andsolubility of carbon dioxide in commercial polycaprolactone(PCL) at elevated pressure, in order toproperly design and develop a SC-CO2-based processessuch as the production of drug loaded microparticles ormonolithic matrices. Duarte et al. (2006) used arudimental gravimetric method to determine the amountof absorbed carbon dioxide by recording desorptionkinetics after releasing the pressure and retrieving thepolymer sample from the autoclave at defined timeintervals. The error caused by the time lag until thesample is placed on a microbalance should be avoidedby detecting the weight online under pressure.