INVESTIGADORES
CENTRON Daniela
artículos
Título:
Class 2 integrons dissemination among multidrug resistance (MDR) clones of Acinetobacter baumannii
Autor/es:
. RAMÍREZ MS, MORALES A, VILACOBA E, MÁRQUEZ C, ARGENTINIAN INTEGRON STUDY GROUP, AND CENTRÓN D.
Revista:
CURRENT MICROBIOLOGY
Editorial:
SPRINGER
Referencias:
Lugar: Berlin; Año: 2012 vol. 64 p. 290 - 293
ISSN:
0343-8651
Resumen:
Acinetobacter baumannii has emerged as a
serious problem in the hospital environment at a global
scale. Previous results from our laboratory showed a high
frequency of class 2 integrons in A. baumannii strains from
Argentina regarding the low rate of this element in
A. baumannii isolates from the rest of the world. To reveal
the current epidemiology of class 2 integrons, a molecular
surveillance analyzing 78 multidrug resistant (MDR)
A. baumannii isolates from Argentina and Uruguay was
performed, exposing the presence of class 2 integron in the
36.61% of the isolates. Class 2 integron characterization
showed that the typical Tn7::In2-7 array was present in 26
out of 27 intI2 positive isolates. All intI2 positive isolates
contained at least one of the Tn7 transposition genes. In
addition, we identified that 18 intI2 positive isolates possessed
the Tn7::In2-7 within the attTn7 site. The molecular
typing evidenced that clones I and IV that do not belong to
widespread European clones I and II were found among the
intI2 positive isolates. Our results exposed the widely
dissemination of class 2 integron among MDR A. baumannii
isolates from Argentina and Uruguay, also showing
the persistence of two novel clones in our region, which
could explain in part the high frequency of class 2 integron
found in our region.