NADES-MEDIATED FOLK PLANT EXTRACTS AS NOVEL ANTIFUNGAL AGENTS AGAINST Candida albicans

ESPINO, MAGDALENA; SOLARI, MANUEL; DE LOS ÁNGELES FERNÁNDEZ, MARÍA; BOITEUX, JOANA; GÓMEZ, MARÍA ROXANA; SILVA, MARÍA FERNANDA

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2019

0731-7085

ABSTRACTCandida albicans is an opportunistic pathogenic yeast commonly found in mouth, gastrointestinal tract andvagina. Under certain conditions, it causes skin, mucosal and systemic infections. With growing concern overthe emergence of resistant strains to conventional antifungals, the development of novel antifungal agents for the management of this pathogen is an urgent need. In the present work, novel bioextracts from folk medicinal plants were directly used as active ingredient in a topical formulation for dermal candidiasis. With the aim to replace hazardous traditional reagents, a natural solvent composed by lactic acid: glucose: water (LGH) was used as vehicle for bioactive compound extraction. Furthermore, phenolic and alkaloid composition were determined by HPLC and their individual antifungal effect was evaluated. LGH extracts of Larrea spices demonstrate a significant antimicrobial activity against C. albicans being higher than their individual bioac-tive constituents. Notably, the mixture of Larrea cuneifolia and L divaricata extracts in topical formulationsreveal a synergistic antifungal effect highlighting their potential for candidiasis treatment.