Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline vaccine-associated sarcomas

SANTELICES IGLESIAS OA; WRIGHT C; DUCHENE AG; RISSO MA; RISSO P; ZANUZZI C; NISHIDA F; LAVID A; CONFENTE F; DÍAZ M; PORTIANSKY E; GIMENO EJ; BARBEITO C

JOURNAL OF COMPARATIVE PATHOLOGY

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2018 vol. 165 p. 45 - 51

0021-9975

Cats vaccine-associated sarcomas (VAS) are mesenchymatic neoplasias developing closed to the areas usually used for the injection of vaccines or other inocula. Adjuvants included in the vaccines are proposed as the triggers of an intense and persistent inflammatory response that would led to the development of the neoplasia. The proinflammatory role of COX-2 is well known and its overexpression has prognostic value in multiple neoplastic processes. One hundred and seventeen selected VAS were histologically processed and the degree of inflammation and of anaplasia were evaluated. The aim of the present study was to correlate the immunohistochemical expression of COX-2 in VAS with the degree of anaplasia and inflammation of these sarcomas. Our results showed that there is a statistically significant association between the degree of inflammation and the expression of COX-2 by neoplastic cells and that its expression is lower in VAS with the higher degrees of anaplasia. These findings may be useful for predicting sensitivity of VAS to specific treatments.