INVESTIGADORES
PORTIANSKY enrique Leo
artículos
Título:
Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger
Autor/es:
CAMILIÓN MC; ; PORTIANSKY EL; PÉREZ NG; REBOLLEDO OR; CINGOLANI HE
Revista:
CARDIOVASCULAR RESEARCH
Editorial:
OXFORD UNIV PRESS
Referencias:
Año: 2002 vol. 53 p. 862 - 868
ISSN:
0008-6363
Resumen:
OBJECTIVE: Experiments were performed to examine the effect of chronic inhibition of the Na(+)/H(+) exchanger isoform-1 (NHE-1) on cardiac hypertrophy of spontaneously hypertensive rats (SHR). METHODS: SHR were orally treated during 1 month with two different doses (0.3 and 3.0 mg/kg/day) of the NHE-1 inhibitor, cariporide, or nifedipine (10.0 mg/kg/day). RESULTS: The two doses of cariporide did not differ in their effects after 1 month of treatment, since both induced a slight decrease in systolic blood pressure (SBP) of approximately 6 mmHg and regression of the heart weight to body weight ratio (mg/g) from 3.28+/-0.05 to 3.04+/-0.05 (0.3 mg) and 2.99+/-0.10 (3.0 mg, P
