Correlation between COX2 expression with clinical and demographic aspects related to feline injection site sarcomas

SANTELICES IGLESIAS OA; WRIGHT C; GRANDINETTI JAB; ZANUZZI, C; DUCHENE AG; RISSO MA; RISSO P; NISHIDA F; LAVID A; PORTIANSKY EL; GIMENO EJ; BARBEITO CG

Revista de la Sociedad Latinoamericana de Dermatología Veterinaria

Sociedad Latinoamericana de Dermatología Veterinaria

Año: 2022

2711-4120

Feline injection site sarcomas (FISS; also known as vaccine associated sarcomas) are neoplasms of mesenchymal origin believed to arise from the neoplastic transformation of reactive fibroblasts at vaccine or other substance inoculation sites. In a recent study the authors have shown that cyclooxygenase 2 (COX2) expression in FISS is associated with the degree of inflammation and anaplasia of the tumor. The aim of the present work was to study the relationship between COX2 expression with demographic and clinical parameters of FISS. Demographic and clinical data were obtained from remission protocols of sarcomas diagnosed as FISS and from surveys answered by veterinarians. The expression of COX2 was determined by immunohistochemistry. An inverse correlation was observed between COX2 and the average time between recurrences and the age at clinical diagnosis of FISS. No correlation was observed between COX2 and the other studied variables (sex, breed, existence of recurrence, number of recurrences or survival time).