Dopaminergic isoquinolines with hexahydrocyc selective ligands

ROJAS, SEBASTIÁN; PARRAVICINI, OSCAR; F. GARIBOTTO; ANGELINA, EMILIO; ENRIZ R D; ANDUJAR, SEBASTIAN

San Miguel de Tucman

Conferencia; Congreso SAB; 2016

Soc Argentina de BIOFISICA

Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates Dopamine receptors (DR) ligands are potential drug candidates forfor treating neurological treating neurological treating neurological treating neurological treating neurological treating neurological treating neurological treating neurological treating neurological disorders including schizophdisorders including schizophdisorders including schizophdisorders including schizophdisorders including schizophdisorders including schizophdisorders including schizophdisorders including schizophdisorders including schizophdisorders including schizophdisorders including schizophdisorders including schizophdisorders including schizophdisorders including schizophrenia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)renia or Parkinson?s disease. Three series of isoquinolines: (E)-1-styrylstyrylstyrylstyryl-1,2,3,41,2,3,41,2,3,41,2,3,41,2,3,4-tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7tetrahydroisoquinolines (series 1), 7-phenyl 1,2,3,7,8,8aphenyl 1,2,3,7,8,8aphenyl 1,2,3,7,8,8aphenyl 1,2,3,7,8,8aphenyl 1,2,3,7,8,8aphenyl 1,2,3,7,8,8aphenyl 1,2,3,7,8,8aphenyl 1,2,3,7,8,8aphenyl 1,2,3,7,8,8aphenyl 1,2,3,7,8,8aphenyl 1,2,3,7,8,8aphenyl 1,2,3,7,8,8aphenyl 1,2,3,7,8,8aphenyl 1,2,3,7,8,8aphenyl 1,2,3,7,8,8a-hexahydrocyclopenta hexahydrocyclopenta hexahydrocyclopenta hexahydrocyclopenta hexahydrocyclopenta hexahydrocyclopenta hexahydrocyclopenta hexahydrocyclopenta hexahydrocyclopenta hexahydrocyclopenta hexahydrocyclopenta hexahydrocyclopenta hexahydrocyclopenta hexahydrocyclopenta [ij]-IQs (HCPIQs) series 2) and E)IQs (HCPIQs) series 2) and E)IQs (HCPIQs) series 2) and E)IQs (HCPIQs) series 2) and E)IQs (HCPIQs) series 2) and E)IQs (HCPIQs) series 2) and E)IQs (HCPIQs) series 2) and E)IQs (HCPIQs) series 2) and E)IQs (HCPIQs) series 2) and E)IQs (HCPIQs) series 2) and E)IQs (HCPIQs) series 2) and E)IQs (HCPIQs) series 2) and E)IQs (HCPIQs) series 2) and E)IQs (HCPIQs) series 2) and E)IQs (HCPIQs) series 2) and E)IQs (HCPIQs) series 2) and E)-1-(prop-1-en-1-yl)yl)-1,2,3,41,2,3,41,2,3,41,2,3,4- tetrahydroisoquinolines (seriestetrahydroisoquinolines (seriestetrahydroisoquinolines (seriestetrahydroisoquinolines (seriestetrahydroisoquinolines (seriestetrahydroisoquinolines (seriestetrahydroisoquinolines (seriestetrahydroisoquinolines (seriestetrahydroisoquinolines (seriestetrahydroisoquinolines (seriestetrahydroisoquinolines (seriestetrahydroisoquinolines (seriestetrahydroisoquinolines (seriestetrahydroisoquinolines (seriestetrahydroisoquinolines (seriestetrahydroisoquinolines (seriestetrahydroisoquinolines (seriestetrahydroisoquinolines (series 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 3), were prepared to determine their affinity for both D1 and D2 -like DR. The effect of like DR. The effect of like DR. The effect of like DR. The effect of like DR. The effect of like DR. The effect of like DR. The effect of like DR. The effect of like DR. The effect of like DR. The effect of like DR. The effect of like DR. The effect of like DR. The effect of like DR. The effect of different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function different substituents on the nitrogen atom (methyl or allyl), dioxygenated function (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b (methoxyl or catechol), the substituent at b -position of the THIQ skeletposition of the THIQ skeletposition of the THIQ skeletposition of the THIQ skeletposition of the THIQ skeletposition of the THIQ skeletposition of the THIQ skeletposition of the THIQ skeletposition of the THIQ skeletposition of the THIQ skeletposition of the THIQ skeletposition of the THIQ skeletposition of the THIQ skeletposition of the THIQ skeletposition of the THIQ skeletposition of the THIQ skeletposition of the THIQ skeleton, and the on, and the on, and the on, and the on, and the on, and the on, and the on, and the on, and the on, and the presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most presence or absence of the cyclopentane motif, were studied. We observed that most active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity for D2for D2for D2-like DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol grouplike DR and these remarkable features: a catechol group in the IQin the IQin the IQin the IQin the IQ-ring and the Nring and the Nring and the Nring and the Nring and the Nring and the Nring and the Nring and the Nring and the Nring and the Nring and the Nring and the N-substitution (methyl or allyl). propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b propenyl. Therefore, the substituent at b -position of the THIQ and position of the THIQ and position of the THIQ and position of the THIQ and position of the THIQ and position of the THIQ and position of the THIQ and position of the THIQ and position of the THIQ and position of the THIQ and position of the THIQ and position of the THIQ and position of the THIQ and position of the THIQ and position of the THIQ and position of the THIQ and position of the THIQ and the cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affthe cyclopentane ring also modulated this affinity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, inity. Among these dopaminergic isoquinolines, HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2HCPIQs stood out for unexpected selectivity to D2-DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached DR since the Ki D1/D2 ratio reached values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in values of 2465, 1010 and 382 for compounds 3a, 3c 3e, respectively. Finally, in agreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental datagreement with the experimental data, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most a, molecular modeling studies on DRs of the most characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR characteristic ligands of the three series revealed stronger molecular interactions with D2 DR than with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DRthan with D1 DR, which further supports to the encountered enhanced selectivity D2 DR1.