Gastric cytoprotective activity of ilicic aldehyde. Structure-activity

O. J. DONADEL, E. GUERREIRO†, A. O. MARÍA, G. WENDEL, R. D. ENRIZ, O. S.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Elsevier

Lugar: Amsterdam; Año: 2005 vol. 15 p. 3547 - 3550

0960-894X

A series of sesquiterpene compounds possessing both eudesmane and eremophilane skeletons were tested as gastric cytoprotective agents on male Wistar rats. The presence of an a,b-unsaturated aldehyde on the C-7 side chain together with a hydroxyl group at C-4 is the requirement for the observed antiulcerogenic activity. In an attempt to establish new molecular structural requirements for this gastric cytoprotective activity, a structure–activity study was performed.a,b-unsaturated aldehyde on the C-7 side chain together with a hydroxyl group at C-4 is the requirement for the observed antiulcerogenic activity. In an attempt to establish new molecular structural requirements for this gastric cytoprotective activity, a structure–activity study was performed.