INVESTIGADORES
ENRIZENRIZ] ricardoricardo] danieldaniel]
artículos
Título:
Antioxidan and Cytotoxic Activity of Canadine. Biological Effects and Structural Aspects
Autor/es:
E. CORRECHE, S.ANDUJAR, R.KURDELAS, M.J.GOMEZ LECHON, M.L.FREILE AND R.D.ENRIZENRIZ]
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY.
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 2008 vol. 16 p. 3641 - 3641
ISSN:
0968-0896
Resumen:
Abstract—The cytotoxic effects of four alkaloids, berberine, canadine, anonaine, and antioquine were evaluated using three different  cell cultures, a primary culture (rat hepatocytes) and two cell lines (HepG2 and HeLa). Our results indicate that berberine, anonaine, and antioquine possess a significant the cytotoxic effect. In contrast, canadine does not possess cytotoxic effect at concentrations tested here. A molecular modeling study indicates that the quaternary nitrogen, the aromatic polycyclic and planar structure of berberine- cell cultures, a primary culture (rat hepatocytes) and two cell lines (HepG2 and HeLa). Our results indicate that berberine, anonaine, and antioquine possess a significant the cytotoxic effect. In contrast, canadine does not possess cytotoxic effect at concentrations tested here. A molecular modeling study indicates that the quaternary nitrogen, the aromatic polycyclic and planar structure of ber- The cytotoxic effects of four alkaloids, berberine, canadine, anonaine, and antioquine were evaluated using three different  cell cultures, a primary culture (rat hepatocytes) and two cell lines (HepG2 and HeLa). Our results indicate that berberine, anonaine, nd antioquine possess a significant the cytotoxic effect. In contrast, canadine does not possess cytotoxic effect at concentrations that the potential of this alkaloid as a novel class of antioxidant agent is very interesting and deserves further research. The cytotoxic effects of four alkaloids, berberine, canadine, anonaine, and antioquine were evaluated using three different  cell cultures, a primary culture (rat hepatocytes) and two cell lines (HepG2 and HeLa). Our results indicate that berberine, anonaine, nd antioquine possess a significant the cytotoxic effect. In contrast, canadine does not possess cytotoxic effect at concentrations that the potential of this alkaloid as a novel class of antioxidant agent is very interesting and deserves further research. The cytotoxic effects of four alkaloids, berberine, canadine, anonaine, and antioquine were evaluated using three different  cell cultures, a primary culture (rat hepatocytes) and two cell lines (HepG2 and HeLa). Our results indicate that berberine, anonaine, nd antioquine possess a significant the cytotoxic effect. In contrast, canadine does not possess cytotoxic effect at concentrations that the potential of this alkaloid as a novel class of antioxidant agent is very interesting and deserves further research.
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