INVESTIGADORES
D'ATTILIO luciano david
congresos y reuniones científicas
Título:
Levels of Gal-1 and Gal-3 in plasma and pleural fluids from patients with Tuberculosis, and its relation with immune-endocrine parameters
Autor/es:
FERNANDEZ, ROCÍO; D'ATTILIO LUCIANO; SANTUCCI NATALIA; CERCIANI JUAN PABLO; POCHETTINO ARÍSTIDES; BERTOLA DIEGO; BOTTASSO OSCAR; RABINOVICH GABRIEL; BAY MARÍA LUISA,
Lugar:
Buenos Aires
Reunión:
Congreso; IV LASID Meeting LXIII Argentinean Immunology Society Meeting II French-Argentinean Immunology Meeting; 2015
Institución organizadora:
LASID-SAI-FAIC
Resumen:
Our former studies in patients with pulmonary tuberculosis (PTB) showed markedly decreased plasma levels of dehydroepiandrosterone (DHEA) together with augmented concentrations of cortisol and pro-inflammatory cytokines. Pleural TB patients (PLTB) that mount a better anti-mycobacterial immune response revealed even further increased levels of pro-inflammatory cytokines and reduced cortisol and DHEA concentrations in their pleural fluids (PF) compared their peripheral compartment. Given the well known immunomodulatory effects of galectins (Gal) which may impact on the endocrine response as well, we also measured concentrations of Gal-1 and Gal-3 (ELISA) in PF and plasma (P) from PLTB patients (n=11), and P from PTB (n=38) cases with no pleural affectation and healthy controls (HCo; n=24). PTB patients had higher Gal-1 levels in P respect the PLTB counterparts and HCo (p
