STUDIES ON THE NEURO-IMMUNE-ENDOCRINE INTERACTIONS DURING PULMONARY OR PLEURAL TUBERCULOSIS.

D'ATTILIO LUCIANO DAVID,; SANTUCCI NATALIA; DÍAZ ARIANA; BONGIOVANNI BETTINA; DÍDOLI GRISELDA; BERTOLA DIEGO; GARDEÑEZ WALTER,; BOTTASSO OSCAR; BAY MARÍA L

Buenos Aires

Congreso; IV LASID Meeting LXIII Argentinean Immunology Society Meeting II French-Argentinean Immunology Meeting; 2015

LASID-SAI-FAIC

Tuberculosis is a major health problem worldwide, mostly affecting the lungs, although pleural tuberculosis (TBPL) can be a frequent extrapulmonary manifestation. The natural course of both clinical forms is different, partly because of the type of immune response developed in the two compartments. The immune system receives and sends messages to the central nervous system modulating each other, through the Hypothalamus Pituitary Adrenal axis and the autonomous nervous system (ANS). To get some insight on the complex neuro-immune-endocrine (NIE) interactions encompassing TB, we analyzed the relationship between compounds from the ANS (A:adrenaline; NA:noradrenaline and D:Dopamine; -HPLC-), the endocrine system (Cortisol, dehydroepiandrosterone -DHEA and DHEA-S, Growth hormone -GH- and IGF-1;-ELISA-) and immune mediators (IL-1β, IL-6, TNF-α, IL-18, IFN-γ, TGF-β;-ELISA-) in plasma (P) and pleural fluid (PF) of patients with TBP (n=46), TBPL (n=12) and healthy controls (n=32). Both patient groups had increased amounts of pro- and anti-inflammatory cytokines (p