T CD4+ CD25+ FOXP3+ REGULATORY CELLS AND ITS RELATIONSHIP WITH IMMUNE-ENDOCRINE MEDIATORS DURING PULMONARY TUBERCULOSIS TREATMENT

DÍAZ ARIANA; SANTUCCI NATALIA; BONGIOVANNI BETTINA; D'ATTILIO LUCIANO; DÍDOLI GRISELDA; LIOI SUSANA; MASSONI CLAUDIA; RADCLIFFE SUSANA; GARDEÑEZ WALTER,; BOTTASSO OSCAR; BAY MARÍA L

Canela

Congreso; VII MEETING OF THE SLAMTB; 2014

SLAMTB

Tuberculosis (TB) is a major health problem that requires an appropriate cell immune response (IR) to be controlled, with an exacerbated IR being involved in tissue damage. Since regulatory T cells (Tregs) are relevant in the regulation of the IR, we analyzed Tregs variations throughout the course of TB treatment and its relationship with changes in immune-endocrine mediators dealing with disease immunopathology. The cohort was initially composed of 41 adult patients, 20 of the completing treatment and follow-up, with neither HIV co-infection nor multidrug resistant TB. Patients were bled at diagnosis (T0) and at 2 (T2), 4 (T4), 6 (T6) and 9 months following treatment initiation. Twenty four age- and sex-matched healthy controls (HCo) as well as 14 household contacts (HHC, according to a model of latent infection), were also included. Plasma cytokines were assessed by ELISA; Cortisol and Dehydroepiandrosterone sulfate (DHEA-S) by electrochemiluminescence and Tregs frequency by flow cytometry. Tregs from TB patients were increased at T0 (vs. HCo p