High pressure assessment of bilayered electrospun vascular grafts by means of an electroforce biodynamic system

R.L. ARMENTANO; D. VALDEZ JASSO; L.J. CYMBERKNOP; F. MONTINI BALLARÍN; D. VELEZ; P.C. CARACCIOLO; G.A. ABRAHAM

Milán

Conferencia; 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society of the IEEE Engineering in Medicine and Biology Society (EMBC'15).; 2015

IEEE Engineering in Medicine and Biology Society

Tissue engineering offers the possibility of developing a biological substitute material in vitro with the inherent properties required in vivo.However, the inadequate performance in vascular replacement of small diameter vasculargrafts (VG) reduces considerably the current alternatives in this field. Inthis study, a bilayered tubular VG was produced, where its mechanical responsewas tested at high pressure ranges and compared to a native femoral artery.Materials and Method: The VG was obtained using sequential electrospinningtechnique, by means of two blends of Poly(L-lactic acid) and segmentedpoly(ester urethane). Mechanical testing was performed in a biodynamic systemand the pressure-strain relationship was used to determine the elastic modulus.Results: Elastic modulus assessed value of femoral artery at a high pressurerange (33.02x106 dyn/cm2) was founded to be 36% the magnitude of VG modulus(91.47x106 dyn/cm2) at the same interval. Conclusion: A new circulating mock incombination with scan laser micrometry have been employed for the mechanicalevaluation of bioresorbable bilayered VGs. At same pressure levels, graftelasticity showed a purely collagenic behavior with respect to a femoralartery response.