Modulated and targeted release of new antitumoral glycosides from graft copolymers of PCL macromonomer onto polyacrylic chains

ABRAHAM,G.A.; GALLARDO,A.; SAN ROMAN,J; FERNANDEZ MAYORALAS,A.; ZURITA,M.; VAQUERO,J.

Barcelona, España

Congreso; 18th European Conference on Biomaterials, European Society for Biomaterials; 2002

Recently, a second generation of compounds with simplified structures that inhibited the proliferation of human glioma cell in culture and transplanted glioma in rats, were synthesized and tested. Thus, the design of an intracranially-implanted drug delivery system capable of releasing this glycoside for several days appear to be interesting. Several systems for releasing antitumoral agents have been described in the literature. One promising and alternative support for controlled drug release to be implanted in situ after brain cancer surgery, is described here. The combination of structures with hydrophobic/hydrophilic chains can lead to the control of the biodegradation rate of the grafted polyester moieties and finally can modulate the drug release from the matrix. In this work, partially-biodeg1radable graft copolymers of poly(e-caprolactone) (PCL) on poly(dimethylacrylamide) (PDMAm) and/or poly(methyl methacrylate) (PMMA), are proposed as drug delivery systems for the release of a glycoside model.