The antitumoral effects of HO-1 in colorectal cancer are dependent on the presence of a wild type p53

ALONSO E.N.; GANDINI N.A.; FERRONATO M.J.; FERMENTO M.E.; MARQUESTAUT M.N.; ANDRÉS, N.C.; ABBA, M.C.; MASILLO C.L.; CURINO A. C.; FACCHINETTI M.M.

Mar del Plata

Congreso; LXI Reunión Anual de la Sociedad Argentina de Investigaciones Clínicas (SAIC); 2016

Sociedad Argentina de Investigación Clínica (SAIC)

Previously, we reported that heme oxygenase-1 (HO-1) is associated with increased overall survival time of patients with invasive colorectal cancer (CRC) and that HO-1 activation decreases the viability of human CRC cell lines that carry a wild-type p53 although it has no effect on cells with absent/mutated p53. The hypothesis of this work is that p53 might be involved in the antitumoral effect of HO-1 in CRC. By using a xenograft of p53 wild type-containing HCT116, we first demonstrated that genetic overexpression of HO-1 delayed tumor growth (p