INVESTIGADORES
CURINO Alejandro Carlos
congresos y reuniones científicas
Título:
Heme oxygenase-1 decreases the invasive phenotype in breast cancer
Autor/es:
CURINO A. C.; FERRONATO M.J.; ALONSO E.N.; FERMENTO M.E.; OBIOL D.J.; FACCHINETTI M.M.; GANDINI N.A.
Lugar:
Bariloche
Reunión:
Simposio; Symposium in Signal Transduction and Molecular Medicine (SISTAM2015); 2015
Resumen:
HEME OXYGENASE-1 DECREASES THE INVASIVE FENOTYPE IN BREAST CANCERCurino Alejandro Carlos; Ferronato María Julia; Alonso Eliana Noelia; Fermento María Eugenia; Obiol Diego Javier, Facchinetti María Marta; Gandini Norberto Ariel. Laboratorio de Biología del Cáncer- INIBIBB-CCT Bahía Blanca, Argentina. acurino@criba.edu.arABSTRACTCell invasion involves changes in cell-cell and cell-extracellular matrix interactions. The E-cadherin (E-cadh) and β-catenin (β-cat) participate as anchor proteins of epithelial cell-cell and have been deregulated in breast cancer (BC). Previous results from our laboratory demonstrated the role of heme oxygenase 1 (HO-1) in the progression of BC. The aim of this work was to study the role of HO-1 in the modulation of these proteins and the regulation of cell migration and invasion. In human BC biopsies, we detected by immunohistochemistry (IHC), that there is a positive correlation between the expression of HO-1 and E-cadh (p = 0.0144; Spearman test). In the murine LM3 BC cells we observed by immunofluorescence and western blot (WB) increased expression of E-cadh and β-cat (p