Short-Term In Vivo Response to Anodized Magnesium Alloy as a Biodegradable Material for Bone Fracture Fixation Devices

MERLO JULIETA; M . KATUNAR; TANO DE LA HOZ; CARRIZO SABRINA; SALEMME ALONSO, L; OTAZ, M. A; BALLARRE, JOSEFINA; CERE, SILVIA

ACS Applied Bio materials

ACS

Año: 2021

Biodegradable materials based on magnesium alloyshave a huge potential for bone fracture fixation devices due to theiradequate mechanical properties and biocompatibility. However, theirfast degradation and the consequent liberation of hydrogen gas at theinitial stages of implantation is the major limitation for their use. Inthis study, the AZ91D magnesium alloy was surface treated by anenvironment-friendly, nontoxic, and low-cost anodizing process andthe early in vivo response was studied in a rat transcortical model.Adequate maturation of woven bone around implantsdetected atday 7 post implantationto lamellar bone was observed from day15. Lamellar bone after 15 and 30 days of implantation presentedsimilar volume, mineralization pattern, mineral to protein content,and estimated bone maturity between anodized AZ91D and polylactic acid (control) implants. Histology observation showedneither release of hydrogen bubbles in the region closed to the anodized AZ91D implant nor systemic effects on liver, kidney, andspleen. Thus, anodizing of AZ91D in the conditions stated here induced an adequate short-term in vivo response, which postulatestheir use as potential biodegradable fracture fixation devices for bone healing.