Effect of anodised zirconium implants on early osseointegration process in adult rats: A histologic and histomorphometric study

TANO DE LA HOZ, MF; KATUNAR, M.R; GOMEZ SANCHEZ, A; GONZALEZ, ARIEL ; A. DIAZ; CERE

Progress in Biomaterials

Springer

Año: 2019 vol. 3 p. 1 - 10

2194-0509

Since surface plays a key role in bioactivity, the response of the host to the biomaterialwill determine the success of failure of the prosthesis. The purpose of this study is tomake an exhaustive analysis of the histological and histochemical characteristics of newbone tissue around Zr implants anodised at 60V (Zr60) supported by histomorphometricmethods in a rat model. Fibrous tissue was observed around the control implants (Zr0)and osteoblasts were identified on the trabeculae close to the implantation site thatshowed typical cytological characteristics of active secretory cells, regardless thesurface condition. The histomorphometrical analysis revealed a significant increase incancellous bone volume, trabecular thickness and in trabecular number together with adecrease in trabecular separation facing Zr60. TRAP staining showed that there was arelative increase in the number of osteoclasts for the Zr60. In addition, a larger numberof osteroclast with a greater number of nuclei were detected in the tibiae for Zr60. Thisresearch demonstrated that the new bone microarchitecture in contact with Zr60 is ableto improve the early stages of the osseointegration process and consequently theprimary stability of implants which is a crucial factor to reduce recovery time forpatients.