Acantholippia salsoloides: Phytochemical Composition and Biological Potential of a Thujonic Population

LILIANA S CELAYA; LUIS R SILVA; CARMEN I VITURRO

NATURAL PRODUCT COMMUNICATIONS

NATURAL PRODUCTS INC

Lugar: Westerville, Ohio; Año: 2019 vol. 14 p. 1 - 7

1934-578X

Acantholippia salsoloides (Verbenaceae) is an aromatic plantwidespread in the Andean region. The infusion (leaves and flowers) is widelyused as a digestive stimulant as well as for the treatment of various diseasesin traditional medicine. In this work, two different polar extracts and the essentialoil of a selected rica-rica population were studied. The phenolic compositionwas analyzed by HPLC-DAD; the essential oil profile was determined byGC-IT-MS/FID. For all extracts, the antibacterial potential was performed by in vitro assays; the antioxidant and α-glucosidase inhibition were determinedin decoction and hydroethanolic extracts. The volatile profile allowed theidentification of twenty-six volatile compounds; being β-thujone (84%) the major one in this rica-rica population.Eighteen phenolic compounds were identified; isoferulic acid (16?18%) andcynaroside (45?47%) were the larger ones. In a general way, the hydroethanolicextract was more active against Staphylococcusaureus and Micrococcus luteus(MICs= 0.3- 1.3 mg/mL). Both polar extracts have strong antiradical activitiesalthough decoction extract proved to be more active against DPPH? (IC50=36 µg/mL) and O2●- (IC50 =28 µg/mL) whilehydroethanolic extract shows higher action over α-glucosidase (IC50 =217 µg/mL). The results suggestthat A. salsoloides leaves andflowers may be an interesting source of natural antioxidants, antidiabetics orantimicrobials, and could be used in dietary supplements, medicinal productsand pharmaceutical formulations.