ONLINE MODELING OF ENDOGLUCANASES FROM ASPERGILLUS GENUS USING PHYRE2

COSSIO, M; SIOLI, GA; PERONA, G; CASTRILLO, ML; ZAPATA, PD

Oro Verde, Entre Rios

Congreso; 3er Congreso Argentino de Bioinformática y Biología Computacional; 2012

Cellulolytic enzymes are generally induced as multienzyme systems and they have been divided, according to cellulose fiber cleaving region, into three classes endoglucanases, cellobiohydrolases  and β-glucosidases. Endoglucanases are extracellular enzymes that degrade cellulose to lower molecular weight sugars and can be found on wood decomposing fungi [1]. Researchers are now focusing their view in this field due to the potential application of these enzymes in bioethanol production. Protein models provide us useful information about structure, global interactions with membrane complexes and other proteins, number and location of hydrophobic and hydrophilic residues and molecular weight, among other things. All previously mentioned would allow us to make inferences about kinetic and enzymatic properties of endoglucanases having just their aminoacidic sequence as real data.