D-- phenotype caused by a novel RHCE null allele

PRINCIPI C; TRUCCO BOGGIONE C; ENSINCK A; POSNER V; LUJÁN BRAJOVICH M; STETTLER S; MATTALONI S; BIONDI C; COTORRUELO C

Transfusion

John Wiley and Sons Inc

Año: 2024 vol. 64 p. 3 - 5

A new hybrid RHCE null allele, denoted here RHCE*ce(48C)-D(3-7)-CE and designated by the ISBT as RHCE*01N.16, was found to be responsible for a D- - phenotype showing exalted D antigen expression. The loss of native RhCE proteins interactions may relieve some steric hindrance and increase D epitopes presentation at the membrane surface resulting in an overexpression of the D antigen4. This is an unusual phenotype in all populations.