Deletion of E and e antigen in a pregnan woman

COTORRUELO C; BIONDI C; GARCÍA ROSASCO M; FORESTO P; RACCA A; VALVERDE J

TRANSFUSION

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Baltimore; Año: 1996 vol. 36 p. 191 - 192

0041-1132

The Rh System is of clinical importance because it is involved in the pathogenesis of hemolytic disease of the newborn, autoimmune hemolytic anemias and hemolytic transfusion reactions. We present a case of a pregnant woman who was referred to our service because of a complicated obstetrical and transfusion history. Our evaluation demonstrated that the patient´s blood group was O, RhD+. An IgG, 37ºC reactive, noncomplement-binding antibody was identified in her serum. It reacted with all red cells except Rhnull and CD-/CD-. Neither E nor e could be identified on the mother?s red cells by using 10 different antisera These findings suggest that our patient has anti-Hr0 . We report this case of deletion of E and e as another example of a very unusual phenotype. Patients with these unusual phenotypes present difficulties with regard to pregnancy or transfusion needs. We this in mind, we had the patient donate blood so that compatible red blood cells would be available for either the mother or the newborn. She has since given to a pre-term infant with hemolytic disease of the newborn, who was successfully treated with phototherapy.