INVESTIGADORES
SALVA Maria Susana
congresos y reuniones científicas
Título:
NASAL ADMINISTRATION OF LACTOBACILLUS RHAMNOSUS IMPROVES THE NUMBER AND ACTIVITY OF LUNG ANTIGEN-PRESENTING CELLS IN MALNOURISHED MICE
Autor/es:
BARBIERI, NATALIA; VILLENA, JULIO; HERRERA, MATÍAS; SALVA, SUSANA; ALVAREZ, SUSANA
Lugar:
Los Cocos, Córdoba
Reunión:
Congreso; LXI Reunión Anual de la Sociedad Argentina de Inmunología (SAI); 2013
Institución organizadora:
Sociedad Argentina de Inmunología
Resumen:
In this work, we studied the effect of nasally administered Lactobacillus rhamnosus CRL1505 (Lr) on the number and activity of lung antigen-presenting cells (APC), during the dietary recovery of malnourished mice. Weaned mice were malnourished with a protein-free diet (PFD) for 21d. Malnourished mice received balanced conventional diet (BD) during 7d (BD group) or BD with nasal Lr supplementation (108cells/mouse/d) during last 2 days of the treatment (BD+Lr group). The malnourished control mice (MC) received PFD while the well-nourished control group (WC) consumed BD. Changes in lung CD11c-CD11b+F4-80+monocytes (Mo), CD11c+CD11b-/lowF4-80+AF+macrophages (Ma) and myeloid CD11c+F4-80-AF-CD11b+ and CD11c+F4-80-AF-B220+ plasmacytoid dendritic cells (DC) were evaluated by flow cytometric analysis. In addition, MHC-II expression in these cell populations was studied. Malnutrition significantly reduced the number of lung Mo, Ma and DCs (p
