INVESTIGADORES
SALVA Maria Susana
congresos y reuniones científicas
Título:
Protein malnutrition affects the development of b lymphocytes in bone marrow and spleen
Autor/es:
SALVA SUSANA; MERINO CECILIA; VILLENA JULIO; GRUPPI ADRIANA; ALVAREZ SUSANA
Lugar:
Tafí del Valle. Tucumán
Reunión:
Jornada; XXVI Jornadas Científicas de la Asociación de Biología de Tucumán; 2009
Institución organizadora:
Asociación de Biología de Tucumán
Resumen:
Protein malnutrition decreases resistance to infection due to the alteration of various physiological processes, including hematopoiesis. This work evaluated the effect of protein malnutrition on the ontogeny and function of spleen and bone marrow (BM) B lymphocytes (LB). Weaning mice were malnourished by protein deficiency for 21d (M). Control mice (C) received balanced conventional diet. In M and C groups it was evaluated: expression of B220, HSA and IgM in BM and spleen cells by flow cytometry, total IgM and IgG levels in culture supernatants of spleen LB, stimulated with LPS or CpG, and proliferative capacity of spleen LB. Malnutrition decreased significantly the total cell number of BM and spleen, mainly affecting the population of LB (B220+). In BM, the M group showed a marked decrease in immature LB population (B220lowHSAhighIgM+/-) (p
