INVESTIGADORES
SALVA Maria Susana
congresos y reuniones científicas
Título:
Stimulation of phagocytes by Lactobacillus strains in immunocompromised hosts
Autor/es:
VILLENA JULIO; PACHECO VICTORIA; SALVA SUSANA; ALVAREZ SUSANA
Lugar:
Tafí del Valle. Tucumán
Reunión:
Jornada; XXVI Jornadas Científicas de la Asociación de Biología de Tucumán; 2009
Institución organizadora:
Asociación de Biología de Tucumán
Resumen:
We evaluated the effect of different probiotic Lactobacillus (Lb) on the number and activity of phagocytic cells in mice immunosuppressed by cyclophosphamide (Cf). Lb rhamnosus CRL1505 (LR5), Lb rhamnosus CRL1506 (LR6) and Lb casei CRL431 (LC) were selected previously in immunocompetent mice. Adult mice were administered LR5, LR6 or LC. After each treatment, these groups and control mice (C) received an intraperitoneal (ip) injection of Cf (150 mg/kg) and were sacrificed at different times post-chemotherapy (for 15d). We studied: a) peritoneal macrophages (PMf) phagocytic activity, b) neutrophil number and peroxidase activity (Px) in blood, c) expression of Gr-1 in blood by flow cytometry, and d) Candida albicans (Ca) clearance after an ip challenge. Mice treated with the Lb strains showed a higher PMf activity when compared with the C group (P
