INVESTIGADORES
SAAVEDRA Maria Lucila
artículos
Título:
Microcin J25-Ga induces apoptosis in mammalian cells by inhibiting mitochondrial RNA-polymerase
Autor/es:
NIKLISON-CHIROU MV; DUPUY F; SAAVEDRA L; BANCHIO C; MINAHK C; MORERO RD
Revista:
PEPTIDES
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Año: 2011 vol. 32 p. 832 - 834
ISSN:
0196-9781
Resumen:
MccJ25, anantimicrobial peptide,was unable to cause apoptosis of COS-7cells inspite of inducingreactive-oxygen speciesoverproductionaswellascytochrome c release fromisolatedmitochondria.Surprisingly, MccJ25-Ga,anamidatedvariantofMccJ25thatdisplayssimilaranti-mitochondrialeffects,did induceapoptosisinCOS-7.Theonlydifferencefoundbetweentheactivitiesofthesepeptideswastheunpredicted inhibitionofmitochondrialRNAsynthesisbyMccJ25-Ga.Theseresultsledustohypothesizethat bothmitochondrialRNApolymeraseandmitochondrialmembranemightbethemoleculartargetsof MccJ25-Gainmitochondriaandthiscombinedeffectmayleadtoapoptosis.
