Antibacterial activity of Caesalpinia paraguariensis extracts

SGARIGLIA, M.A.; SOBERÓN, J.R.; QUIROGA, E.N.; VATTUONE, M.A.

Tucumán (Argentina)

Congreso; XXII Annual Meeting of Tucuman Biology Society; 2005

Tucuman Biology Society (publicado en Bio Cell 30 (1))

The ethnomedicinal use of plants reveals their importance as source of bioactive compounds and orients us toward the search of new substances with potential therapeutic applications. The objective of this study was to validate the antibacterial (AB) activity of extracts of a native species of Argentinean North, used in popular medicine as vulnerary. Guayac.n (Fabaceae) bark extracts (Infusion (I), Decoction (D) and Tincture (T)), according Argentine Pharmacopoeia VI Ed., were assayed against 22 bacteria: Gram (+) and Gram (-) isolated from superficial wounds, ATCC and plant pathogenic bacteria (CECT). Broth microdilution and agar macrodilution techniques were employed in Muller Hinton (MH) medium. MIC and MBC values were determined. All tests were performed by quadruplicate. The extracts have a wide antibacterial activity, showing an evident growth inhibition and bacterial death on all the assayed strains. MIC values of I and D were 20-300 and 24,9-398,7 mg. Extracted Material / 100 ml, respectively, that are higher than T AB activity (20-650). MBC values were coincident or higher than MIC values.