Antifungal activity of a Ligaria cuneifolia metabolite and combination with commercial antifungals against Candida albicans

SOBERÓN, J.R.; SGARIGLIA, M.A.; SAMPIETRO, D.A.; VATTUONE, M.A.

Horco Molle ? Yerba Buena - Tucumán - Argentina

Congreso; XXIX Annual Scientific Meeting of Tucuman Biology Society; 2013

Tucuman Biology Society

In recent years, fungal infections have increased prevalently in immunocompromised hosts. Candida spp. represents one the major causes of fungal infections. Commonly used antifungal drugs are toxic to hosts or act as fungistatic, leading to antifungal resistance development, making necessary to find more effective and safe antifungal drugs. A compound isolated from Ligaria cuneifolia leaves methanolic extract, called MLC7, was assayed alone and combined with commercial antifungal drugs against C. albicans (ATCC 10231). Minimal inhibitory concentration (MIC) for MLC7 was 5 μg . mL-1, with fungistatic activity. Combination assays with Amphotericin B (AMB) showed additive effects between them, with combined inhibitory activity=1,05. The association between these drugs could be used to diminish the therapeutic doses for AMB along with its nephrotoxic effects. We are carrying out assays to elucidate the chemical structure of MLC7 and its action mode.