Lipid peroxidation inhibitory activity of components isolated from Caesalpinia paraguariensis stem bark infusion

SGARIGILA, M.A.; SOBERÓN , J.R.; SAMPIETRO, D.A.; QUIROGA, E.N.; VATTUONE, M.A.

Molecular Medicinal Chemistry

INSTITUTO DE INVESTIGACIÓN DE LAS CIENCIAS EXACTAS FÍSICAS Y NATURALES

Lugar: Buenos Aires; Año: 2013

1666-888X

The lipid peroxidation is a chain reaction initiated by free radicals which produce oxidative damage on polyunsaturated fatty acids. The lipid oxidation is implicated in physiopathology of atherosclerosis. Accordingly, substances capable of neutralizing free radicals can inhibiting the lipid peroxidation and contribute with an anti-atherosclerotic effect. The stem bark of a tree named ?Guayacán? (Caesalpinia paraguariensis), was used in argentine north as water additive of ?mate? in order to diminish blood cholesterol level or prevent the atherosclerosis. Because of this, we investigated the infusion, their purified fractions and compounds isolated by bioguided purification, according to their ability to inhibiting the lipid peroxidation on biological membranes; with the purpose of validating the usage (at least partially) and identify the components responsible for the observed effect.