Inhibitory effect of Lactobacilli on the growth and biofilm production of Klebsiella strain associated with catether

NC MALDONADO ; M CECILIA ; C SILVA ; ME NADER-MACÍAS

Tafi del Valle

Otro; XXII Jornadas Científicas. Asociación de Biología de Tucumán; 2006

Asociación de Biología de Tucumán

Infections related with catheters and other devices are a challenge for prevention and treatment; therapies are not always effective due to new virulence mechanisms developed by microorganisms: production of biofilms. To avoid catheter - associated infections a great variety of technological innovation has been applied but without success. Recently, OMS recommended bacteriotherapy. Numerous studies have shown the protecting effect exerted by lactic acid bacteria (LAB) against diverse range of infections. The objective of the present study was to examine the inhibition of the formations of biofilms and growth of catheter-associated Klebsiella by using Lactobacillus strains. For the inhibition assaying the O? Toole technique was used. A decrease of between 3 and 7 log regarding bacterial growth, whereas biofilms productions was completely inhibited. Inhibition of biofilm formation and growth of Klebsiella by lactobacilli and their acid and neutral supernatant could indicate useful and economical alternative method for prevention of catheter-associated bacterial infections.