Lactobacillus reuteri CRL1101 beneficially modulate lipopolysaccharide-mediated inflammatory response in a mouse model of endotoxic shock

GUILLERMO JUAREZ; JULIO VILLENA; SUSANA SALVA; GRACIELA FONT; VIRGINIA RODRIGUEZ

Journal of Functional Foods

Elsevier SCIENCE

Año: 2013

1756-4646

Lactobacillus reuteri CRL1101 was found to reduce inflammatory and oxidative damage during endotoxic shock induced by lipopolysaccharide (LPS) administration in mice. This ben- eficial effect was related to the capacity of both the cell structure as well as their secreted products to act synergistically to induce a tolerogenic profile in immune cells. The study supports the idea that, although probiotic microorganisms may exert their beneficial effects due to their well-known ability to modulate intestinal immunity, these effects are not restricted to the gastrointestinal tract. In addition, we demonstrated that the in vitro screening of lactobacilli strains is still a powerful approach to discriminate the potential probiotic bacteria for specific functions that could be later studied in animal models. From the systematic studies reported here, L. reuteri CRL1101, a strain with technological poten- tial usefulness in dairy products, is proposed as novel probiotic candidate for the prevention and control of systemic inflammatory disorders.