Polyclonal dissemination of KPC-2 in Serratia marcescens, including a clone with epidemic behavior in the nosocomial niche

RODRIGUEZ C; BRENGI S; CÁCERES MA; MOCHI S; VIÑAS MR; MERLETTI G; RAYA R; CENTRON D

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2017 vol. 49 p. 657 - 658

0924-8579

Serratia marcescens is a nosocomial pathogen frequently isolated from outbreaks with high morbidity and mortality [1?3]. Several nosocomial outbreaks have been described caused by the dispersion of epidemic clones carrying class 1 integrons [1?3], some of which also harbour Klebsiella pneumoniae carbapenemase-2 (KPC-2) in carbapenem-resistant S. marcescens nosocomial isolates [3,4], rendering phenotypes of extreme antimicrobial resistance. Previously, we have identified multidrug-resistant (MDR) S. marcescens strains belonging to epidemic cluster IX circulating since 2002 in Argentinian nosocomial isolates 2. This cluster was susceptible to carbapenems and harboured class 1 integrons. Later, a significant increase in the frequency of carbapenem-resistant S. marcescens nosocomial isolates (19,5/11,9, absolute/expected annual frequency) was identified in a hospital of northern Argentina (H1) between 2013-2014.