Inflammation-hemostasis relationship in infected malnourished mice: modulatory effect of Lactobacillus casei CRL 431

ZELAYA HORTENSIA; CECILIA HARO; LAIN ̃O JONATHAN; SUSANA ALVAREZ; AGÜERO GRACIELA

INFLAMMATION RESEARCH

BIRKHAUSER VERLAG AG

Lugar: BASEL; Año: 2012 vol. 4 p. 1 - 11

1023-3830

Objective and design: The coagulation system is considered part of the defense machinery, but its excessive activation can lead to additional damage. We studied the effects of oral administration of Lactobacillus casei CRL431 a probiotic bacterium, on the activation of coagulation and the relationship with inflammatory parameters during a respiratory infection in malnourished mice. Materials and methods:Malnourished Swiss albino mice were nourished with a balanced commercial diet (BCD) for 7 days or BCD with L. casei for the last 2 days (BCD-Lc). BCD, BCD-Lc, malnourished (MNC) and well-nourished controls (WNC) were infected with Streptococcus pneumoniae. Blood and bronchoalveolar lavage samples were obtained at different times post-infection. Results and conclusions: Malnutrition altered most of the evaluated parameters before and after infection. The repletion diet with supplemental L. casei was the most effective in limiting coagulation-activation and normalizing coagulation-inhibition mechanisms. These findings will help develop further strategies to reduce the damaging effects of clotting and enhance its beneficial contribution to immune reactions.