Aflatoxin B1 residues in liver of Japanese quail (Coturnix japonica) exposed to contaminated feed and exogenous corticosterone

MAGNOLI; CHIACCHIERA, S. M.; DA ROCHA ROSA, C. A.; DALCERO, A. M.; MARIN R. H.

REVISTA BRASILEIRA DE MEDICINA VETERINARIA

SOC MEDICINA VETERINARIA ESTADO RIO DE JANEIRO

Lugar: SOC MEDICINA VETERINARIA ESTADO RIO DE JANEIRO; Año: 2013 vol. 35 p. 378 - 384

0100-2430

The combined effect of aflatoxin B1 (AFB1) exposition and stress induced by corticosterone(CORT) upon the residual aflatoxin levels in livers of Japanese quail wasexamined. A total of 144 Japanese quail (Coturnix japonica) were divided into 6 treatmentswith 6 replicates per treatment, each containing 2 males and 2 females. The differenttreatments resulted from the combination of the presence or absence of CORT indrinking water (5 mg/L) with the presence or absence of AFB1 supplementation (100or 500 ng/g). Dietary treatments were offered from 5 to 11 weeks of age. The differentdiets were: Treatment (T) 1: basal diet (B) AFB1 (15 ng/g); T2: B plus AFB1 (100 ng/g);T3: B plus AFB1 (500 ng/g); T4: B plus CORT (5 mg/L); T5: B plus AFB1 (100 ng/g)and CORT (5 mg/L); and T6: B plus AFB1 (500 ng/g) and CORT (5 mg/L). The residuallevels of AFB1 were remarkably higher in livers of birds fed with AFB1 in comparisonwith those belonging to the group that received a combination of AFB1 and CORT (P<0.05). A plausible explanation about the facts that could be responsible for observedreduction in the toxin carryover in liver was suggested. These results are very strikingand may constitute the start point for a series of studies that aim to elucidate the preciseinfluence of hypothalamic-pituitary-adrenal axis (HPA) response to stress in birdsexposed to AFB1.