Novel Poly(ester urethane urea)/Polydioxanone Blends: Electrospun Fibrous Meshes and Films

ADHIKARI, KIRAN R.; STANISHEVSKAYA, INESSA; CARACCIOLO, PABLO C.; ABRAHAM, GUSTAVO A.; THOMAS, VINOY

MOLECULES

MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI

Año: 2021 vol. 26

1420-3049

In this work, we report the electrospinning and mechano-morphological characterizationsof scaffolds based on blends of a novel poly(ester urethane urea) (PHH) and poly(dioxanone) (PDO). At the optimized electrospinning conditions, PHH, PDO and blend PHH/PDO in Hexafluroisopropanol (HFIP) solution yielded bead-free non-woven random nanofibers with high porosity and diameter in the range of hundreds of nanometers. The structural, morphological, and biomechanical properties were investigated using Differential Scanning Calorimetry, Scanning Electron Microscopy, Atomic Force Microscopy, and tensile tests. The blended scaffold showed an elastic modulus (~5 MPa) with a combination of the ultimate tensile strength (2 +/- 0.5 MPa), and maximum elongation (150% +/- 44%) in hydrated conditions, which are comparable to the materials currently being used for soft tissue applications such as skin, native arteries, and cardiac muscles applications. This demonstrates the feasibility of an electrospun PHH/PDO blend for cardiac patches or vascular graft applications that mimic the nanoscale structure and mechanical properties of native tissue.