Effect of processing techniques on new PCL-embelin microparticles of biomedical interest

P.R. CORTEZ TORNELLO; A. TAPIA; G. FERESIN; M. DZIECIUCH; T.R. CUADRADO; G.A. ABRAHAM

ADVANCES IN POLYMER TECHNOLOGY

JOHN WILEY & SONS INC

Lugar: New York; Año: 2018 vol. 37 p. 1570 - 1580

0730-6679

Poly(e-caprolactone) microparticles containing embelin (PCLE) are prepared by electrohydrodynamic atomization (EHDA) and emulsion-solventevaporation techniques. Microparticles are characterized in terms of drug state, drug-loading capacity, encapsulation efficiency, morphology and in vitro release in different mediums. Physicochemical, morphological, and thermal characterization is presented. Kinetic analysis is performed. EHDA microparticles present higher size, surface area, and encapsulation efficiency. The release profiles combine a high initial release, followed by a slow-controlled release stage. Electrosprayed PCLE presented characteristics such as size (3.14 ± 0.05 ìm), zeta potential (−49.22 ± 2.88 mV) and release profiles that could be attractive for the development of microcarriers for pulmonary administration of embelin.