Mechanical behavior of bilayered small-diameter nanofibrous structures as biomimetic vascular grafts

F. MONTINI BALLARIN; D. CALVO; P.C. CARACCIOLO; F. ROJO; P.M. FRONTINI; G.A. ABRAHAM; G. GUINEA-TORTUERO

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016 vol. 60 p. 220 - 233

1751-6161

To these days, the production of a small diameter vascular graft (< 6 mm) with an appropriate and permanent response is still challenging. The mismatch in the grafts mechanical properties is one of the principal causes of failure, therefore their complete mechanical characterization is fundamental. In this work the mechanical response of electrospun bilayered small-diameter vascular grafts made of two different bioresorbable synthetic polymers, segmented poly(ester urethane) and poly(L-lactic acid), that mimic the biomechanical characteristics of elastin and collagen is investigated. A J-shaped response when subjected to internal pressure was observed as a cause of the nanofibrous layered structure, and the materials used. Compliance values were in the order of natural coronary arteries and very close to the bypass gold standard-saphenous vein. The suture retention strength and burst pressure values were also in the range of natural vessels. Therefore, the bilayered vascular grafts presented here are very promising for future application as small-diameter vessel replacements.