INVESTIGADORES
ABRAHAM Gustavo abel
artículos
Título:
Central neural tumor destruction by controlled release of a synthetic glycoside dispersed in a biodegradable polymeric matrix
Autor/es:
FERNANDEZ MAYORALAS,A.; DE LA FIGUERA,N.; ZURITA,M.; VAQUERO,J.; ABRAHAM,G.A.; SAN ROMAN,J; NIETO SAMPEDRO,M.
Revista:
JOURNAL OF MEDICINAL CHEMISTRY
Editorial:
Americal Chemical Society
Referencias:
Lugar: Easton,PA, USA.; Año: 2003 vol. 46 p. 1286 - 1288
ISSN:
0022-2623
Resumen:
An octyl N-acetylglucosaminide derivative with a pentaerythritol chain at position 6 has been synthesized and evaluated as inhibitor of neural tumor growth. The glycoside inhibited the growth of a neuroectodermic tumor implanted in rats, and, when loaded on a slow-delivery polymer disc, caused the destruction of cultured human astroblastoma obtained after surgical biopsy.
